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When NNMT activity is elevated — as documented in obese adipose tissue, several cancer types, and aged skeletal muscle — intracellular NAD+ availability decreases, SAM availability decreases, and downstream sirtuin activity (particularly SIRT1 and SIRT3) is reduced
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mg:10mg/10mg X 5pk
[DOI] [PMC free article] [PubMed] [Google Scholar] 81.Zhang H., Hao Y., Manor B., Novak P., Milberg W., Zhang J., Fang J., Novak V
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